Scintigraphic evaluation of oesophageal transit during radiotherapy to the mediastinum
Identifieur interne : 008558 ( Main/Exploration ); précédent : 008557; suivant : 008559Scintigraphic evaluation of oesophageal transit during radiotherapy to the mediastinum
Auteurs : Giuseppe Sasso [Italie, Australie, France] ; Pierfrancesco Rambaldi [Italie] ; Francesco S. Sasso [Italie] ; Vincenzo Cuccurullo [Italie] ; Paola Murino [Italie] ; Paolo Puntieri [Italie] ; Hugo R. Marsiglia [France, Espagne, Italie] ; Luigi Mansi [Italie]Source :
- BMC Gastroenterology [ 1471-230X ] ; 2008.
Abstract
To quantitatively evaluate radiation-induced impaired oesophageal transit with oesophageal transit scintigraphy and to assess the relationships between acute oesophagitis symptoms and dysmotility.
Between January 1996 and November 1998, 11 patients affected by non-small-cell carcinoma of the lung not directly involving the oesophagus, requiring adjuvant external beam radiotherapy (RT) to the mediastinum were enrolled. Oesophageal transit scans with liquid and semisolid bolus were performed at three pre-defined times: before (T0) and during radiation at 10 Gy (T1) and 30 Gy (T2). Two parameters were obtained for evaluation: 1) mean transit time (MTT); and 2) ratio between peak activity and residual activity at 40 seconds (ER-40s). Acute radiation toxicity was scored according to the joint EORTC-RTOG criteria. Mean values with standard deviation were calculated for all parameters. Analysis of variance (ANOVA) tests and paired t-Tests for all values were performed.
An increase in the ER-40s from T0 to T1 or T2 was seen in 9 of 11 patients (82%). The mean ER-40s value for all patients increased from 0.8306 (T0) to 0.8612 (T1) and 0.8658 (T2). These differences were statistically significant (p < 0.05) in two paired t-Tests at T0 versus T2 time: overall mean ER-40s and upright ER-40s (p = 0.041 and p = 0.032, respectively). Seven patients (63%) showed a slight increase in the mean MTT value during irradiation but no statistically significant differences in MTT parameters were found between T0, T1 and T2 (p > 0.05).
Using oesophageal scintigraphy we were able to detect early alterations of oesophageal transit during the third week of thoracic RT.
Url:
DOI: 10.1186/1471-230X-8-51
PubMed: 18986522
PubMed Central: 2611991
Affiliations:
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Sasso</name><affiliation wicri:level="1"><nlm:aff id="I1">Radiation Oncology Department, Second University of Naples, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Radiation Oncology Department, Second University of Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Cuccurullo, Vincenzo" sort="Cuccurullo, Vincenzo" uniqKey="Cuccurullo V" first="Vincenzo" last="Cuccurullo">Vincenzo Cuccurullo</name><affiliation wicri:level="1"><nlm:aff id="I2">Nuclear Medicine Department, Second University of Naples, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Nuclear Medicine Department, Second University of Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Murino, Paola" sort="Murino, Paola" uniqKey="Murino P" first="Paola" last="Murino">Paola Murino</name><affiliation wicri:level="1"><nlm:aff id="I1">Radiation Oncology Department, Second University of Naples, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Radiation Oncology Department, Second University of Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Puntieri, Paolo" sort="Puntieri, Paolo" uniqKey="Puntieri P" first="Paolo" last="Puntieri">Paolo Puntieri</name><affiliation wicri:level="1"><nlm:aff id="I2">Nuclear Medicine Department, Second University of Naples, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Nuclear Medicine Department, Second University of Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Marsiglia, Hugo R" sort="Marsiglia, Hugo R" uniqKey="Marsiglia H" first="Hugo R" last="Marsiglia">Hugo R. Marsiglia</name><affiliation wicri:level="1"><nlm:aff id="I5">Radiation Oncology Department, Institut Gustave Roussy, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Radiation Oncology Department, Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="I6">Radiation Oncology Division, IMO International Oncology Group, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Radiation Oncology Division, IMO International Oncology Group, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I7">Faculty of Medicine and Surgery, University of Florence, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Faculty of Medicine and Surgery, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Mansi, Luigi" sort="Mansi, Luigi" uniqKey="Mansi L" first="Luigi" last="Mansi">Luigi Mansi</name><affiliation wicri:level="1"><nlm:aff id="I2">Nuclear Medicine Department, Second University of Naples, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Nuclear Medicine Department, Second University of Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Gastroenterology</title><idno type="eISSN">1471-230X</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>To quantitatively evaluate radiation-induced impaired oesophageal transit with oesophageal transit scintigraphy and to assess the relationships between acute oesophagitis symptoms and dysmotility.</p></sec><sec sec-type="methods"><title>Methods</title><p>Between January 1996 and November 1998, 11 patients affected by non-small-cell carcinoma of the lung not directly involving the oesophagus, requiring adjuvant external beam radiotherapy (RT) to the mediastinum were enrolled. Oesophageal transit scans with liquid and semisolid bolus were performed at three pre-defined times: before (T0) and during radiation at 10 Gy (T1) and 30 Gy (T2). Two parameters were obtained for evaluation: 1) mean transit time (MTT); and 2) ratio between peak activity and residual activity at 40 seconds (ER-40s). Acute radiation toxicity was scored according to the joint EORTC-RTOG criteria. Mean values with standard deviation were calculated for all parameters. Analysis of variance (ANOVA) tests and paired t-Tests for all values were performed.</p></sec><sec><title>Results</title><p>An increase in the ER-40s from T0 to T1 or T2 was seen in 9 of 11 patients (82%). The mean ER-40s value for all patients increased from 0.8306 (T0) to 0.8612 (T1) and 0.8658 (T2). These differences were statistically significant (p < 0.05) in two paired t-Tests at T0 versus T2 time: overall mean ER-40s and upright ER-40s (p = 0.041 and p = 0.032, respectively). Seven patients (63%) showed a slight increase in the mean MTT value during irradiation but no statistically significant differences in MTT parameters were found between T0, T1 and T2 (p > 0.05).</p></sec><sec><title>Conclusion</title><p>Using oesophageal scintigraphy we were able to detect early alterations of oesophageal transit during the third week of thoracic RT.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>France</li><li>Italie</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Sasso, Giuseppe" sort="Sasso, Giuseppe" uniqKey="Sasso G" first="Giuseppe" last="Sasso">Giuseppe Sasso</name></noRegion><name sortKey="Cuccurullo, Vincenzo" sort="Cuccurullo, Vincenzo" uniqKey="Cuccurullo V" first="Vincenzo" last="Cuccurullo">Vincenzo Cuccurullo</name><name sortKey="Mansi, Luigi" sort="Mansi, Luigi" uniqKey="Mansi L" first="Luigi" last="Mansi">Luigi Mansi</name><name sortKey="Marsiglia, Hugo R" sort="Marsiglia, Hugo R" uniqKey="Marsiglia H" first="Hugo R" last="Marsiglia">Hugo R. Marsiglia</name><name sortKey="Murino, Paola" sort="Murino, Paola" uniqKey="Murino P" first="Paola" last="Murino">Paola Murino</name><name sortKey="Puntieri, Paolo" sort="Puntieri, Paolo" uniqKey="Puntieri P" first="Paolo" last="Puntieri">Paolo Puntieri</name><name sortKey="Rambaldi, Pierfrancesco" sort="Rambaldi, Pierfrancesco" uniqKey="Rambaldi P" first="Pierfrancesco" last="Rambaldi">Pierfrancesco Rambaldi</name><name sortKey="Sasso, Francesco S" sort="Sasso, Francesco S" uniqKey="Sasso F" first="Francesco S" last="Sasso">Francesco S. Sasso</name></country><country name="Australie"><noRegion><name sortKey="Sasso, Giuseppe" sort="Sasso, Giuseppe" uniqKey="Sasso G" first="Giuseppe" last="Sasso">Giuseppe Sasso</name></noRegion></country><country name="France"><noRegion><name sortKey="Sasso, Giuseppe" sort="Sasso, Giuseppe" uniqKey="Sasso G" first="Giuseppe" last="Sasso">Giuseppe Sasso</name></noRegion><name sortKey="Marsiglia, Hugo R" sort="Marsiglia, Hugo R" uniqKey="Marsiglia H" first="Hugo R" last="Marsiglia">Hugo R. Marsiglia</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Marsiglia, Hugo R" sort="Marsiglia, Hugo R" uniqKey="Marsiglia H" first="Hugo R" last="Marsiglia">Hugo R. Marsiglia</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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